Investigator(s)
| WHO Technical Officer |
Edit Oktavia Manuama WHO Indonesia Edit Oktavia Manuama 
|
| Principal Investigator |
Dr. Detty Siti Nurdiati Center for Child Health - Pediatric Research Office, University of Gadjah Mada Dr. Detty Siti Nurdiati
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| Co-Investigator(s) |
Dr.Indah Kartika Murni Center for Child Health - Pediatric Research Office, University of Gadjah Mada Dr.Indah Kartika Murni
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| Co-Investigator(s) |
Dr. Likke Prawidya Putri Center for Child Health - Pediatric Research Office, University of Gadjah Mada Dr. Likke Prawidya Putri
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| Co-Investigator(s) |
Bayu Satria Wiratama Center for Child Health - Pediatric Research Office, University of Gadjah Mada Bayu Satria Wiratama
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| Co-Investigator(s) |
Dr. Vicka Oktaria Center for Child Health - Pediatric Research Office, University of Gadjah Mada Dr. Vicka Oktaria
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Title(s) and abstract
| Scientific title | Retrospective Assessment of the impact of COVID-19 on pregnancy and newborn outcomes : an explanatory sequential mixed method study |
| Public title | Assessment of impact of COVID 19 on Pregnancy and Newborn outcomes |
| Background | Numerous studies have highlighted that COVID 19 has a more severe effect on pregnant women compared to the non-pregnant women group. The physiological and immunological changes that occur during pregnancy increase the pregnant women with COVID-19 risk for severer hypoxia and cytokine and complement activation. To our knowledge, recently there has been some studies on COVID-19 and pregnancy outcomes in Indonesia but they are conducted at a small scale and substantial heterogeneity of study methods, target population, and findings are notable. Therefore, in the context like Indonesia where its health system and quality of maternal and newborn care issues are complex, more original studies are required to support evidence generation on impact of COVID-19 on pregnancy outcomes. |
| Objectives | This study's primary objectives is to assess the impact of COVID-19 infection status in pregnancy on maternal complications, birth outcomes and newborn status. The secondary objectives are: 1. To compare maternal characteristics, complications and birth outcomes among pregnant women with COVID-19 during pregnancy by COVID-19 severity. 2. To explore the extent of maternal service disruptions and readiness of healthcare facilities during COVID-19 pandemic. |
| Study Methods | This is an explanatory sequential mixed method study combining a retrospective cohort and followed by qualitative data collection and analysis. The quantitative study will observe two main outcomes, including maternal and neonatal outcomes. Maternal outcomes will include maternal mortality, pregnancy completion (abortion or delivery, including spontaneous, induction, or cesarean section), and pre-eclampsia. Neonatal outcomes will include neonatal mortality, stillbirth, poor fetal outcome (fetal distress, stillbirth, premature, low birth weight), Apgar score at 5 minutes, and neonatal infection. The quantitative study will target 4,024 pregnant woman-baby dyads. To explore supply-side readiness in providing COVID-19-related services, a qualitative study will be conducted use in-depth interviews of hospital managers, obstetricians, pediatrician/neonatologists, and chief of triage (emergency) and data will be qualitatively analyzed using thematic analysis. |
| Expected outcomes and use of results | This study primarily contributes to generate knowledge, information on medical care given to women in COVID-19 outbreak areas who are pregnant or planning pregnancy, as well as to better understanding of the contributing factors to the adverse outcomes of pregnancy with COVID-19. Knowledge about the clinical presentation and severity of COVID-19 during pregnancy, the prevalence of symptomatic and asymptomatic infections, pregnancy outcomes, the potential for teratogenicity, and the potential for mother-to-child transmission are some of the topics that are expected to be studied. Although there is no direct advantage to lists of sampled pregnant women, and their treatment and their outcomes, the findings from this study will allow us to draw lesson learned on preventing future unfavorable outcomes of pregnant women diagnosed with COVID-19. |
| Keywords | COVID 19, pregnancy, maternal, neonatal |
Research Details
| Student research | No |
| Start Date | 01-Jan-2023 |
| End Date | 30-Jun-2023 |
| Key Implementing Institution | Center for Child Health-Pediatric Research Office |
| Multi-country research | No |
| Nationwide research | Yes, with randomly selected geographical areas |
| Indonesia, Indonesia, Indonesia, Indonesia | |
| Research Domain(s) | Maternal, Reproductive and Child Health, Communicable Disease Research |
| Research field(s) | COVID-19, Child Health, |
| Involves human subjects | Yes |
| Data Collection | Primary and secondary data |
| Proposal reviewed by other Committee | Under Review |