Investigator(s)
| WHO Technical Officer |
Anupama Hazarika World Health Organization, Country Office for Bangladesh Anupama Hazarika 
|
| Principal Investigator |
Afrin Iqbal International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) Afrin Iqbal
|
| Co-Investigator(s) |
Shams El Arifeen International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) Shams El Arifeen
|
| Co-Investigator(s) |
Mohammad Mehedi Hasan International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) Mohammad Mehedi Hasan
|
| Co-Investigator(s) |
Quamrun Nahar International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) Quamrun Nahar
|
| Co-Investigator(s) |
Sarker Masud Parvez International Centre for Diarrheal Disease Research, Bangladesh (icddr,b) Sarker Masud Parvez
|
Title(s) and abstract
| Scientific title | Survey to estimate the prevalence of biomarkers of infection with hepatitis B virus and hepatitis C virus among children aged 2-5 years and pregnant women in Bangladesh |
| Public title | Survey to estimate the prevalence of biomarkers of infection with hepatitis B virus and hepatitis C virus among children aged 2-5 years and pregnant women in Bangladesh |
| Background | Burden: The WHO estimated in 2015 that viral hepatitis led to 1.3 million deaths worldwide. Although all hepatotropic viruses have the potential to infect humans and cause acute hepatitis, hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most responsible factors worldwide for death tolls, with more than a 95% rate. Knowledge gap: This study aims to estimate the prevalence of HBsAg and anti-HCV, along with viral loads of HBV and HCV, in Bangladesh where related studies are limited. Relevance: This biomarker survey can provide reliable population-based estimates of biomarkers of hepatitis B virus and hepatitis C virus (HBsAg and Anti-HCV), enabling a country status in achieving regional and global control and elimination goals. These estimates can be used for modeling, assessing infection burden, and developing a national plan for control and elimination. |
| Objectives | To estimate the prevalence of HBsAg and anti-HCV along with viral load of HBV and HCV in children aged 2-5 years and pregnant women in Bangladesh. Specific Objectives: To estimate the prevalence of HBsAg among children aged 2-5 years in Bangladesh •To estimate the prevalence of HBsAg among pregnant women in Bangladesh •To estimate the prevalence of anti-HCV among children aged 2-5 years in Bangladesh •To estimate the prevalence of anti-HCV among pregnant women in Bangladesh •To estimate the viral load of HBV in HBsAg positive children aged 2-5 years and pregnant women through PCR (HBV-DNA) •To estimate the viral load of HCV in anti-HCV positive children aged 2-5 years and pregnant women through PCR (HCV-RNA) •To find out the immediate source of infection of the 2-5 years old children |
| Study Methods | The population includes children aged 2-5 years and pregnant women, mothers of rapid diagnostic test-positive children and two other family members. The study will use a cross-sectional survey method with a sample size of 3155 children and approximately 909 pregnant women adopting the single-stage stratified cluster method. |
| Expected outcomes and use of results | This biomarker survey will provide reliable population-based estimates of biomarkers of hepatitis B virus and hepatitis C virus (HBsAg and Anti-HCV). These estimates will be used for modeling, assessing infection burden, and developing a national plan for control and elimination by the National Programs of Bangladesh and also inform the global communities. |
| Keywords | Bangladesh; Hepatitis; Hepatitis B; Hapatitis C; HBV; HCV; HBsAg; anti-HCV; Pregnant Women; Children; Prevalence; |
Research Details
| Student research | No |
| Start Date | 15-May-2024 |
| End Date | 31-Mar-2025 |
| Key Implementing Institution | International Centre for Diarrhoeal Disease Research, Bangladesh |
| Multi-country research | No |
| Nationwide research | Yes |
| Research Domain(s) | Communicable Disease Research |
| Research field(s) | |
| Involves human subjects | Yes |
| Population-Based Survey | |
| Data Collection | Primary data |
| Proposal reviewed by other Committee | Final decision available |